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Issue 1, 2015
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Carbon–hydrogen (C–H) bond activation at PdIV: a Frontier in C–H functionalization catalysis

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Abstract

The direct functionalization of carbon–hydrogen (C–H) bonds has emerged as a versatile strategy for the synthesis and derivatization of organic molecules. Among the methods for C–H bond activation, catalytic processes that utilize a PdII/PdIV redox cycle are increasingly common. The C–H activation step in most of these catalytic cycles is thought to occur at a PdII centre. However, a number of recent reports have suggested the feasibility of C–H cleavage occurring at PdIV complexes. Importantly, these latter processes often result in complementary reactivity and selectivity relative to analogous transformations at PdII. This mini review highlights proposed examples of C–H activation at PdIV centres. Applications of this transformation in catalysis as well as mechanistic details obtained from stoichiometric model studies are discussed. Furthermore, challenges and future perspectives for the field are reviewed.

Graphical abstract: Carbon–hydrogen (C–H) bond activation at PdIV: a Frontier in C–H functionalization catalysis

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Publication details

The article was received on 25 Aug 2014, accepted on 18 Sep 2014 and first published on 29 Sep 2014


Article type: Minireview
DOI: 10.1039/C4SC02591A
Citation: Chem. Sci., 2015,6, 70-76
  • Open access: Creative Commons BY license
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    Carbon–hydrogen (C–H) bond activation at PdIV: a Frontier in C–H functionalization catalysis

    J. J. Topczewski and M. S. Sanford, Chem. Sci., 2015, 6, 70
    DOI: 10.1039/C4SC02591A

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