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Issue 5, 2014
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Total synthesis of propolisbenzofuran B

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Abstract

The first total synthesis of propolisbenzofuran B, a bioactive natural product isolated from honeybee propolis resin, is reported. The convergent synthesis makes use of a silicon-tether controlled oxidative ketone–ketone cross-coupling and a novel benzofuran-generating cascade reaction to deliver the core structure of the natural product from readily prepared precursors.

Graphical abstract: Total synthesis of propolisbenzofuran B

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Publication details

The article was received on 01 Feb 2014, accepted on 26 Feb 2014 and first published on 14 Mar 2014


Article type: Edge Article
DOI: 10.1039/C4SC00356J
Author version available: Download Author version (PDF)
Citation: Chem. Sci., 2014,5, 1794-1798
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    Total synthesis of propolisbenzofuran B

    B. T. Jones, C. T. Avetta and R. J. Thomson, Chem. Sci., 2014, 5, 1794
    DOI: 10.1039/C4SC00356J

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