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Issue 6, 2014
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Light-activated antimicrobial surfaces with enhanced efficacy induced by a dark-activated mechanism

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Abstract

Novel bactericidal surfaces were prepared by incorporating crystal violet, methylene blue and 2 nm gold nanoparticles into medical grade silicone using a simple dipping technique. The modified polymers were stable to cleaning by use of an alcohol-based wipe and demonstrated good photostability under intense illumination conditions. The photobactericidal activity of this polymer was compared against a range of other photobactericidal polymers against both Staphylococcus epidermidis and Escherichia coli, under white lighting conditions comparable to that found in a clinical environment. Not only did this novel multi-dye–nanogold–polymer exhibit the strongest photobactericidal activity reported to date, surprisingly, it also demonstrated significant antimicrobial activity under dark conditions.

Graphical abstract: Light-activated antimicrobial surfaces with enhanced efficacy induced by a dark-activated mechanism

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Publication details

The article was received on 19 Nov 2013, accepted on 05 Mar 2014 and first published on 05 Mar 2014


Article type: Edge Article
DOI: 10.1039/C3SC53186D
Citation: Chem. Sci., 2014,5, 2216-2223
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    Light-activated antimicrobial surfaces with enhanced efficacy induced by a dark-activated mechanism

    S. Noimark, E. Allan and I. P. Parkin, Chem. Sci., 2014, 5, 2216
    DOI: 10.1039/C3SC53186D

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