Issue 6, 2014

Highly sensitive and selective detection of the pyrophosphate anion biomarker under physiological conditions

Abstract

A multidentate adsorbate having a bis(carbazolyl)urea unit, as a receptor for hydrogen pyrophosphate anions, and two cyclic bidentate alkyl disulfide groups, as linkers to gold surfaces, has been designed and synthesized. Self-assembled monolayers (SAMs) on gold of this adsorbate have been obtained and characterized showing a high robustness along with an extremely large sensitivity and selectivity for hydrogen pyrophosphate anions enabling to be used as a surface plasmon resonance (SPR) sensor for the detection of such anions at the ppt concentration level under physiological conditions.

Graphical abstract: Highly sensitive and selective detection of the pyrophosphate anion biomarker under physiological conditions

Supplementary files

Article information

Article type
Edge Article
Submitted
05 Nov 2013
Accepted
05 Feb 2014
First published
11 Feb 2014

Chem. Sci., 2014,5, 2328-2335

Author version available

Highly sensitive and selective detection of the pyrophosphate anion biomarker under physiological conditions

G. Sánchez, D. Curiel, W. Tatkiewcz, I. Ratera, A. Tárraga, J. Veciana and P. Molina, Chem. Sci., 2014, 5, 2328 DOI: 10.1039/C3SC53058B

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