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Issue 2, 2015
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A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery

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Abstract

An efficient and gram-scale continuous-flow protocol for the synthesis of the privileged structure 3,4-dihydro-5H-benzo[e][1,4]diazepin-5-one is reported. If compared to the traditional metal mediated non-catalytic reduction procedure, this approach is high yielding and does not require purification steps and therefore could be conveniently used for the generation of compound libraries for drug discovery.

Graphical abstract: A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery

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Publication details

The article was received on 29 Oct 2014, accepted on 27 Nov 2014 and first published on 27 Nov 2014


Article type: Paper
DOI: 10.1039/C4RA13392G
Citation: RSC Adv., 2015,5, 1268-1273
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    A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery

    M. Viviano, C. Milite, D. Rescigno, S. Castellano and G. Sbardella, RSC Adv., 2015, 5, 1268
    DOI: 10.1039/C4RA13392G

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