Jump to main content
Jump to site search

Issue 107, 2014
Previous Article Next Article

Direct C–H amination and C–H chloroamination of 7-deazapurines

Author affiliations

Abstract

Protocols for selective Pd–Cu-catalyzed direct C–H amination or C–H chloroamination of 7-deazapurines with N-chloro-N-alkyl-arylsulfonamides have been developed leading either to 8-(arylsulfonyl)methylamino-7-deazapurines or to 7-chloro-8-(arylsulfonyl)methylamino-7-deazapurines. The scope and limitations of the methods, as well as synthesis of a small series of 6,8,9-tri- and 6,7,8,9-tetrasubstituted 7-deazapurines and deprotection of the sulfonamide are presented.

Graphical abstract: Direct C–H amination and C–H chloroamination of 7-deazapurines

Back to tab navigation

Supplementary files

Publication details

The article was received on 25 Oct 2014, accepted on 12 Nov 2014 and first published on 12 Nov 2014


Article type: Paper
DOI: 10.1039/C4RA13143F
Author version
available:
Download author version (PDF)
Citation: RSC Adv., 2014,4, 62140-62143
  • Open access: Creative Commons BY license
  •   Request permissions

    Direct C–H amination and C–H chloroamination of 7-deazapurines

    N. Sabat, M. Klečka, L. Slavětínská, B. Klepetářová and M. Hocek, RSC Adv., 2014, 4, 62140
    DOI: 10.1039/C4RA13143F

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements