Issue 102, 2014

Simple and effective route for synthesis of parvaquone, an antiprotozoal drug

Abstract

Parvaquone, an antiprotozoal agent against Theileria parva, was synthesized in 33.8% overall yield by using cheap, commercially available raw materials. A key intermediate, 2-cyclohexyl-1-naphthol, was synthesized in 86% yield by cyclohexylation of 1-naphthol and further converted into parvaquone in good yield through reaction sequences such as oxidation and epoxidation followed by isomerization.

Graphical abstract: Simple and effective route for synthesis of parvaquone, an antiprotozoal drug

Supplementary files

Article information

Article type
Communication
Submitted
06 Sep 2014
Accepted
22 Oct 2014
First published
22 Oct 2014

RSC Adv., 2014,4, 58214-58216

Author version available

Simple and effective route for synthesis of parvaquone, an antiprotozoal drug

P. C. Patil and K. G. Akamanchi, RSC Adv., 2014, 4, 58214 DOI: 10.1039/C4RA09934F

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