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Issue 100, 2014
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Expanding the utility of flow hydrogenation – a robust protocol restricting hydrodehalogenation

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Abstract

A commonly observed limitation of conducting hydrogenations under flow chemistry conditions is hydrodehalogenation. In a bid to circumvent this limitation a series of hydrogenation catalysts were screened, with 5% Pt/C (sulfided) catalyst identified as an effective catalyst to selectively effect reductive aminations, nitro reduction, and alkene reductions in the presence of halogen atoms. Additionally the optimised protocol cleanly reduced imines in the presence of a furan moiety indicating potential amenability to other labile functionalities.

Graphical abstract: Expanding the utility of flow hydrogenation – a robust protocol restricting hydrodehalogenation

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Publication details

The article was received on 04 Sep 2014, accepted on 22 Oct 2014 and first published on 23 Oct 2014


Article type: Communication
DOI: 10.1039/C4RA09605C
Citation: RSC Adv., 2014,4, 56743-56748
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    Expanding the utility of flow hydrogenation – a robust protocol restricting hydrodehalogenation

    L. Hizartzidis, P. J. Cossar, M. J. Robertson, M. I. Simone, K. A. Young, A. McCluskey and C. P. Gordon, RSC Adv., 2014, 4, 56743
    DOI: 10.1039/C4RA09605C

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