BF3·OEt2-mediated one pot synthesis of 10-indolyldibenzo[b,f]azepine derivatives via tandem ring expansion and C–C bond formation

Trimurtulu Kotipalli; Donala Janreddy; Veerababurao Kavala; Chun-Wei Kuo; Ting-Shen Kuo; Mei-Ling Chen; Chiu-Hui He; Ching-Fa Yao

doi:10.1039/C4RA08723B

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BF₃·OEt₂-mediated one pot synthesis of 10-indolyldibenzo[b,f]azepine derivatives via tandem ring expansion and C–C bond formation†

Trimurtulu Kotipalli,^a Donala Janreddy,^a Veerababurao Kavala,^a Chun-Wei Kuo,^a Ting-Shen Kuo,^a Mei-Ling Chen,^a Chiu-Hui He^a and Ching-Fa Yao*^a

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* Corresponding authors

^a Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 116, Taiwan
E-mail: cheyaocf@ntnu.edu.tw, cheyaocf@yahoo.com.tw
Fax: +886-2-29324249

Abstract

A simple and efficient one pot protocol was developed for the synthesis of new structurally diverse 10-indolyldibenzo[b,f]azepine derivatives. The reaction involves Lewis-acid mediated ring expansion followed by C–C bond formation through nucleophilic addition of indole moiety.

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DOI: https://doi.org/10.1039/C4RA08723B
Article type: Paper
Submitted: 15 Aug 2014
Accepted: 22 Sep 2014
First published: 23 Sep 2014

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RSC Adv., 2014,4, 47833-47840

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BF₃·OEt₂-mediated one pot synthesis of 10-indolyldibenzo[b,f]azepine derivatives via tandem ring expansion and C–C bond formation

T. Kotipalli, D. Janreddy, V. Kavala, C. Kuo, T. Kuo, M. Chen, C. He and C. Yao, RSC Adv., 2014, 4, 47833 DOI: 10.1039/C4RA08723B

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