Ultrasensitive detection of carcino-embryonic antigen by using novel flower-like gold nanoparticle SERS tags and SERS-active magnetic nanoparticles

Abstract

In this work, an ultrasensitive detection of cancer marker CEA has been developed by using novel gold nanoflowers as SERS tags and SERS-active magnetic nanoparticles as supporting substrates. A good linear relationship between concentration and SERS intensity is found in the range between 0.01 fg mL⁻¹ and 1 ng mL⁻¹, and the LOD is 0.01 fg mL⁻¹.