Issue 70, 2014

Synthesis of glycopolymers at various pendant spacer lengths of glucose moiety and their effects on adhesion, viability and proliferation of osteoblast cells

Abstract

Multivalent glycopolymers containing three different glucose pendant spacer lengths in the polymer backbone having various weight percentages of covalently bonded glucose moieties were obtained by the deacetylation of acetylated polymers synthesized via reversible addition-fragmentation chain transfer (RAFT) process. This allowed us to control the packing density of the glucose moieties in one unit of the glycopolymer. The biological responses of these macromolecules in terms of cytotoxicity of glucose moieties at various spacer lengths and concentrations were investigated without perturbing the intrinsic chemical nature of functional moiety by employing in vitro osteoblast cells. Osteoblast cell adhesion, viability and proliferation response with synthesized glycopolymers revealed that the higher glycopolymer concentration tolerance limit was associated with an increase in pendant spacer length of glucose moiety in the glycopolymer.

Graphical abstract: Synthesis of glycopolymers at various pendant spacer lengths of glucose moiety and their effects on adhesion, viability and proliferation of osteoblast cells

Supplementary files

Article information

Article type
Paper
Submitted
07 Jun 2014
Accepted
30 Jul 2014
First published
30 Jul 2014

RSC Adv., 2014,4, 37400-37410

Author version available

Synthesis of glycopolymers at various pendant spacer lengths of glucose moiety and their effects on adhesion, viability and proliferation of osteoblast cells

M. Trinadh, G. Kannan, T. Rajasekhar, A. V. Sesha Sainath and M. Dhayal, RSC Adv., 2014, 4, 37400 DOI: 10.1039/C4RA05436A

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