Issue 62, 2014
From the journal:

RSC Advances

One-pot route to β-adrenergic blockers via enantioselective organocatalysed epoxidation of terminal alkenes as a key step†

Felix E. Held,a   Shengwei Wei,a   Kathrin Edera  and  Svetlana B. Tsogoeva*a  

* Corresponding authors

a Department of Chemistry and Pharmacy, Chair of Organic Chemistry I and Interdisciplinary Center for Molecular Materials (ICMM), University of Erlangen-Nürnberg, Henkestrasse 42, 91054 Erlangen, Germany
E-mail: svetlana.tsogoeva@fau.fe
Fax: +49-9131-85-26865

Abstract

A convenient and environmentally attractive one-pot two-step process for the synthesis of β-adrenergic blockers via Shi's organocatalytic epoxidation of terminal alkenes and subsequent aminolysis reaction of epoxides with isopropylamine under mild reaction conditions has been developed.

Graphical abstract: One-pot route to β-adrenergic blockers via enantioselective organocatalysed epoxidation of terminal alkenes as a key step

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4RA04011B
Article type
Paper
Submitted
01 May 2014
Accepted
10 Jul 2014
First published
16 Jul 2014
This article is Open Access
Creative Commons BY license

RSC Adv., 2014,4, 32796-32801

Permissions

Request permissions

One-pot route to β-adrenergic blockers via enantioselective organocatalysed epoxidation of terminal alkenes as a key step

F. E. Held, S. Wei, K. Eder and S. B. Tsogoeva, RSC Adv., 2014, 4, 32796 DOI: 10.1039/C4RA04011B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements