Jump to main content
Jump to site search

Issue 39, 2014
Previous Article Next Article

Ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides

Author affiliations

Abstract

Ultrasound-assisted solventless oxidation/reductive amination of benzyl halides was developed as a facile, efficient, and environmental friendly method toward N-alkylated amines. Aldehydes were formed in situ by oxidation of organic halides with N-methylmorpholine N-oxide (NMO), followed by direct reductive amination with amines using sodium borohydride and montmorillonite K-10 catalyst as the reducing system. This green and simple procedure enables N-alkylated amines to be prepared in good to excellent yields with high selectivity of the monoalkylation.

Graphical abstract: Ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Apr 2014, accepted on 25 Apr 2014 and first published on 08 May 2014


Article type: Communication
DOI: 10.1039/C4RA02969K
Author version
available:
Download author version (PDF)
Citation: RSC Adv., 2014,4, 20454-20458
  •   Request permissions

    Ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides

    B. Khumraksa, W. Phakhodee and M. Pattarawarapan, RSC Adv., 2014, 4, 20454
    DOI: 10.1039/C4RA02969K

Search articles by author

Spotlight

Advertisements