Accelerating preclinical PET-screening: reductive amination with [11C]methoxybenzaldehydes

Matthias M. Herth; Sebastian Leth-Petersen; Szabolcs Lehel; Martin Hansen; Gitte M. Knudsen; Nic Gillings; Jacob Madsen; Jesper L. Kristensen

doi:10.1039/C4RA02506G

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Accelerating preclinical PET-screening: reductive amination with [¹¹C]methoxybenzaldehydes†

Matthias M. Herth,*^abc Sebastian Leth-Petersen,^b Szabolcs Lehel,^a Martin Hansen,^b Gitte M. Knudsen,^c Nic Gillings,^a Jacob Madsen^a and Jesper L. Kristensen^b

Author affiliations

* Corresponding authors

^a PET and Cyclotron Unit, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark
E-mail: matthias.herth@nru.dk
Fax: +45 3545 3545
Tel: +45 35458621

^b Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark
Fax: +45 35 33 60 41
Tel: +45 353 36487

^c Center for Integrated Molecular Brain Imaging, Rigshospitalet and University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark
Fax: +45 3545 6713
Tel: +45 3545 6711

Abstract

We report, herein, a simple and efficient labelling strategy for multiple PET tracer preparation using a common intermediate, which has the potential to accelerate preclinical PET radiotracer screening. This procedure was applied to and compared with a previously published labelling strategy illustrating the advantages of this newly developed combinatorial approach.

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Article information

DOI: https://doi.org/10.1039/C4RA02506G
Article type: Communication
Submitted: 21 Mar 2014
Accepted: 29 Apr 2014
First published: 30 Apr 2014

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RSC Adv., 2014,4, 21347-21350

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Accelerating preclinical PET-screening: reductive amination with [¹¹C]methoxybenzaldehydes

M. M. Herth, S. Leth-Petersen, S. Lehel, M. Hansen, G. M. Knudsen, N. Gillings, J. Madsen and J. L. Kristensen, RSC Adv., 2014, 4, 21347 DOI: 10.1039/C4RA02506G

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