Issue 44, 2014
From the journal:

RSC Advances

Viral nanoparticles as antigen carriers: influence of shape on humoral immune responses in vivo†

Deqiang Wei,‡ab   Xia Zhao,‡b   Limin Chen,b   Xingguo Lan,a   Yuhua Li,*a   Yuan Lin*b  and  Qian Wangc  

* Corresponding authors

a College of Life Science, Northeast Forestry University, Harbin 150040, P.R. China
E-mail: lyhshen@126.com
Fax: +86-451-82191733
Tel: +86-451-82191733

b State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P.R. China
E-mail: linyuan@ciac.jl.cn
Fax: +86-431-85262126
Tel: +86-431-85262658

c Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, South Carolina 29208, USA

Abstract

Viral nanoparticles (VNPs) can serve as effective carriers for small molecular haptens with improved humoral immune responses in mice, which is dependent on their shapes. We observed that rod-shaped VNPs elicited higher antibody titers with high specificity compared to spherical VNPs.

Graphical abstract: Viral nanoparticles as antigen carriers: influence of shape on humoral immune responses in vivo

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Article information

DOI
https://doi.org/10.1039/C4RA01821D
Article type
Communication
Submitted
02 Mar 2014
Accepted
13 May 2014
First published
15 May 2014

RSC Adv., 2014,4, 23017-23021

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Viral nanoparticles as antigen carriers: influence of shape on humoral immune responses in vivo

D. Wei, X. Zhao, L. Chen, X. Lan, Y. Li, Y. Lin and Q. Wang, RSC Adv., 2014, 4, 23017 DOI: 10.1039/C4RA01821D

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