Issue 21, 2014
From the journal:

RSC Advances

Enantioselective synthesis of N-allylindoles via palladium-catalyzed allylic amination/oxidation of indolines†

Qiang Zhao,a   Chun-Xiang Zhuoa  and  Shu-Li You*a  

* Corresponding authors

a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China
E-mail: slyou@sioc.ac.cn

Abstract

A highly efficient synthesis of N-allylindoles was realized via palladium-catalyzed asymmetric allylic amination/oxidation sequential reaction of indolines. The N-alkylated indole derivatives were obtained with up to 91% yield and 97% ee.

Graphical abstract: Enantioselective synthesis of N-allylindoles via palladium-catalyzed allylic amination/oxidation of indolines

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Article information

DOI
https://doi.org/10.1039/C4RA00701H
Article type
Communication
Submitted
06 Jan 2014
Accepted
05 Feb 2014
First published
05 Feb 2014

RSC Adv., 2014,4, 10875-10878

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Enantioselective synthesis of N-allylindoles via palladium-catalyzed allylic amination/oxidation of indolines

Q. Zhao, C. Zhuo and S. You, RSC Adv., 2014, 4, 10875 DOI: 10.1039/C4RA00701H

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