Issue 15, 2014
From the journal:

RSC Advances

Reduction with tris(2-carboxyethyl)phosphine (TCEP) enables the use of an S-sulphonate protecting group for thiol-mediated bioconjugation†

Barbara Maret,ab   Thomas Regnier,b   Jean-Christophe Rossi,a   Laurent Garrelly,b   Laurent Viala  and  Robert Pascal*a  

* Corresponding authors

a Institut des Biomolécules Max Mousseron, UMR 5247 CNRS – Universités Montpellier 1 & Montpellier 2, CC17006, Place E. Bataillon, Montpellier, France
E-mail: rpascal@univ-montp2.fr

b COLCOM SARL, Cap Alpha Avenue de l'Europe, Clapiers, France

Abstract

Herein, we demonstrate the effectiveness of the water-friendly S-sulphonate group as an alternative to traditional thiol protecting groups for subsequent deprotection–bioconjugation reactions, under conditions that are compatible with the use of biochemical samples.

Graphical abstract: Reduction with tris(2-carboxyethyl)phosphine (TCEP) enables the use of an S-sulphonate protecting group for thiol-mediated bioconjugation

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Article information

DOI
https://doi.org/10.1039/C3RA47407K
Article type
Communication
Submitted
08 Dec 2013
Accepted
10 Jan 2014
First published
10 Jan 2014

RSC Adv., 2014,4, 7725-7728

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Reduction with tris(2-carboxyethyl)phosphine (TCEP) enables the use of an S-sulphonate protecting group for thiol-mediated bioconjugation

B. Maret, T. Regnier, J. Rossi, L. Garrelly, L. Vial and R. Pascal, RSC Adv., 2014, 4, 7725 DOI: 10.1039/C3RA47407K

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