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Issue 28, 2014
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[C16MPy]AlCl3Br: an efficient novel ionic liquid for synthesis of novel 1,2,4-triazolidine-3-thiones in water

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Abstract

An efficient novel ionic liquid, [C16MPy]AlCl3Br has been synthesized and explored as a catalyst for an eco-friendly synthesis of novel 1,2,4-triazolidine-3-thiones in water at ambient temperature. A variety of aldehydes undergo smooth reaction with thiosemicarbazide and substituted thiosemicarbazides. In the case of substituted thiosemicarbazides the corresponding 1,2,4-triazolidine-3-thiones are obtained as products instead of 1,3,4-oxadiazoles. A broad variety of functional groups are tolerated and a large number of substrates can be applied with this protocol. Rapid eco-friendly reactions with high yields, use of ambient temperature and water as a solvent, easy work-up procedure as well as isolation of product, excellent catalyst recyclability, high atom economy, novelty of ionic liquid as well as the protocol are the auxiliary advantages of the protocol.

Graphical abstract: [C16MPy]AlCl3Br: an efficient novel ionic liquid for synthesis of novel 1,2,4-triazolidine-3-thiones in water

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Publication details

The article was received on 21 Nov 2013, accepted on 06 Mar 2014 and first published on 07 Mar 2014


Article type: Communication
DOI: 10.1039/C3RA46916F
Citation: RSC Adv., 2014,4, 14314-14319
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    [C16MPy]AlCl3Br: an efficient novel ionic liquid for synthesis of novel 1,2,4-triazolidine-3-thiones in water

    J. D. Patil and D. M. Pore, RSC Adv., 2014, 4, 14314
    DOI: 10.1039/C3RA46916F

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