Jump to main content
Jump to site search

Issue 15, 2014
Previous Article Next Article

Transition of chemically modified diphenylalanine peptide assemblies revealed by atomic force microscopy

Author affiliations

Abstract

Self-assembled structures from aromatic dipeptides have attracted a lot of attention. It is highly desirable to produce dipeptide assemblies which undergo structural transitions in response to external stimuli. In this paper, solid nanospheres were successful produced from the self-assembly of chemically modified diphenylalanine in hexafluoroisopropanol (HFIP), a highly polar solvent. Interestingly, after treatment with water, the nanospheres were transformed into nanofibers. The intermediate transition state of nanospheres embedded along the nanofibers was captured by atomic force microscopy (AFM) imaging. In addition, AFM-based nanomechanical measurement revealed the increased stiffness after the transition, suggesting enhanced molecular packing due to favoured intermolecular interactions in water. This study presents a new method to fabricate novel dipeptide structures and provides new information for understanding the mechanism of dipeptide self-assembly driving by intermolecular interactions.

Graphical abstract: Transition of chemically modified diphenylalanine peptide assemblies revealed by atomic force microscopy

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Nov 2013, accepted on 24 Dec 2013 and first published on 03 Jan 2014


Article type: Paper
DOI: 10.1039/C3RA46718J
Citation: RSC Adv., 2014,4, 7516-7520
  •   Request permissions

    Transition of chemically modified diphenylalanine peptide assemblies revealed by atomic force microscopy

    G. Zeng, L. Liu, D. Xia, Q. Li, Z. Xin, J. Wang, F. Besenbacher, T. Skrydstrup and M. Dong, RSC Adv., 2014, 4, 7516
    DOI: 10.1039/C3RA46718J

Search articles by author

Spotlight

Advertisements