An efficient and green procedure for synthesis of rhodanine derivatives by aldol-thia-Michael protocol using aqueous diethylamine medium

Assem Barakat; Abdullah M. Al-Majid; Hany J. AL-Najjar; Yahia N. Mabkhot; Hazem A. Ghabbour; Hoong-Kun Fun

doi:10.1039/C3RA46551A

An efficient and green procedure for synthesis of rhodanine derivatives by aldol-thia-Michael protocol using aqueous diethylamine medium

Assem Barakat,*^a^b Abdullah M. Al-Majid,^a Hany J. AL-Najjar,^a Yahia N. Mabkhot,^a Hazem A. Ghabbour^c and Hoong-Kun Fun^c

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* Corresponding authors

^a Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia
E-mail: ambarakat@ksu.edu.sa
Fax: +966 1-4675992
Tel: +966 1-4675884

^b Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, 21321 Alexandria, Egypt

^c Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia

Abstract

A simple, economical, and green approach to the synthesis of rhodanine derivatives using a tandem aldol condensation-thia-Michael addition process in aqueous diethylamine medium was described. The experiment protocol features simple operations, and the products were isolated in high to excellent yields (82–96%). As spontaneous precipitation always occurs at the end of the process, this leads to easy separation of the products via a simple filtration.

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Publication details

The article was received on 10 Nov 2013, accepted on 02 Dec 2013 and first published on 09 Dec 2013

Article type: Paper

DOI: 10.1039/C3RA46551A

Citation: RSC Adv., 2014,4, 4909-4916

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An efficient and green procedure for synthesis of rhodanine derivatives by aldol-thia-Michael protocol using aqueous diethylamine medium

A. Barakat, A. M. Al-Majid, H. J. AL-Najjar, Y. N. Mabkhot, H. A. Ghabbour and H. Fun, RSC Adv., 2014, 4, 4909
DOI: 10.1039/C3RA46551A
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An efficient and green procedure for synthesis of rhodanine derivatives by aldol-thia-Michael protocol using aqueous diethylamine medium

Abstract

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An efficient and green procedure for synthesis of rhodanine derivatives by aldol-thia-Michael protocol using aqueous diethylamine medium

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