Issue 8, 2014
From the journal:

RSC Advances

Facile preparation of shell crosslinked micelles for redox-responsive anticancer drug release†

Lilong Gao,‡a   Qiaojie Luo,‡b   Ying Wang,a   Hong Du,a   Xiaodong Li,b   Zhiquan Shena  and  Weipu Zhu*a  

* Corresponding authors

a MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China
E-mail: zhuwp@zju.edu.cn
Fax: +86 571 87953727
Tel: +86 571 87953739

b Department of Oral and Maxillofacial Surgery, Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
E-mail: cisarli@zju.edu.cn
Fax: +86 571 87217430
Tel: +86 571 87217430

Abstract

We report a “one-pot” method to synthesize an amphiphilic triblock copolymer with multiple pendant mercapto groups in the hydrophilic block. Shell crosslinked micelles were prepared in a facile manner via the self-assembly of this copolymer in aqueous solution and crosslinking of the micellar shell by H2O2. These shell crosslinked micelles show rapid bioreductive responsiveness for anticancer drug release.

Graphical abstract: Facile preparation of shell crosslinked micelles for redox-responsive anticancer drug release

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Article information

DOI
https://doi.org/10.1039/C3RA41926F
Article type
Communication
Submitted
19 Apr 2013
Accepted
01 Nov 2013
First published
04 Nov 2013

RSC Adv., 2014,4, 4177-4180

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Facile preparation of shell crosslinked micelles for redox-responsive anticancer drug release

L. Gao, Q. Luo, Y. Wang, H. Du, X. Li, Z. Shen and W. Zhu, RSC Adv., 2014, 4, 4177 DOI: 10.1039/C3RA41926F

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