Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.



Synthesis of spiropyrazoline oxindoles by a formal [4 + 1] annulation reaction between 3-bromooxindoles and in situ-derived 1,2-diaza-1,3-dienes

Author affiliations

Abstract

A formal [4 + 1] annulation reaction of 3-bromooxindoles and in situ-derived 1,2-diaza-1,3-dienes in the presence of Cs2CO3 as the base has been developed for the first time. This protocol provides an efficient and mild approach for the synthesis of various biologically interesting spiropyrazoline oxindoles in generally high yields. A one-pot, three-component variant also worked smoothly to give the desired products in comparable yields.

Graphical abstract: Synthesis of spiropyrazoline oxindoles by a formal [4 + 1] annulation reaction between 3-bromooxindoles and in situ-derived 1,2-diaza-1,3-dienes

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 28 Feb 2017, accepted on 25 Mar 2017 and first published on 28 Mar 2017


Article type: Research Article
DOI: 10.1039/C7QO00163K
Citation: Org. Chem. Front., 2017, Advance Article
  •   Request permissions

    Synthesis of spiropyrazoline oxindoles by a formal [4 + 1] annulation reaction between 3-bromooxindoles and in situ-derived 1,2-diaza-1,3-dienes

    D. Chen, W. Xiao and J. Chen, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00163K

Search articles by author