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Issue 9, 2014
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Sonogashira cross-coupling under non-basic conditions. Flow chemistry as a new paradigm in reaction control

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Abstract

The flow regime was implemented as a non-chemical alternative for the reaction control and detrimental acid byproduct sequestration in transition metal catalyzed cross-coupling reactions. The concept was illustrated on the Sonogashira reaction and resulted in a non-basic version of the cross-coupling protocols.

Graphical abstract: Sonogashira cross-coupling under non-basic conditions. Flow chemistry as a new paradigm in reaction control

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Publication details

The article was received on 18 Jul 2014, accepted on 14 Aug 2014 and first published on 26 Aug 2014


Article type: Research Article
DOI: 10.1039/C4QO00198B
Author version available: Download Author version (PDF)
Citation: Org. Chem. Front., 2014,1, 1067-1071
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    Sonogashira cross-coupling under non-basic conditions. Flow chemistry as a new paradigm in reaction control

    S. Voltrova and J. Srogl, Org. Chem. Front., 2014, 1, 1067
    DOI: 10.1039/C4QO00198B

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