Issue 7, 2014

Chopping unfunctionalized carbon–carbon bonds: a new paradigm for the synthesis of organonitriles

Abstract

In the last year, a new strategy for the synthesis of organonitriles, whether aliphatic or aromatic, has emerged based on the direct carbon–carbon double or triple bond cleavage of alkenyl or alkynyl precursors. This Highlight mainly focuses on the efforts made, often nearly simultaneously, by three research teams that shaped the implementation of this new paradigm, which should be of great value for the synthetic community facing the ever-growing demand for new organonitriles, especially in medicinal chemistry.

Graphical abstract: Chopping unfunctionalized carbon–carbon bonds: a new paradigm for the synthesis of organonitriles

Article information

Article type
Highlight
Submitted
28 May 2014
Accepted
19 Jun 2014
First published
20 Jun 2014

Org. Chem. Front., 2014,1, 825-833

Author version available

Chopping unfunctionalized carbon–carbon bonds: a new paradigm for the synthesis of organonitriles

P. Bisseret, G. Duret and N. Blanchard, Org. Chem. Front., 2014, 1, 825 DOI: 10.1039/C4QO00158C

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