Issue 7, 2014

Copper-mediated C(sp2)–H amination using TMSN3 as a nitrogen source: redox-neutral access to primary anilines

Abstract

A Cu-mediated direct conversion of aromatic C–H to C–NH2 assisted by a chelating group was developed. The reaction employed TMSN3 as a nitrogen source under redox-neutral conditions to provide a variety of N-heterocycle-substituted primary anilines. Neither external oxidant nor additional deprotection or reduction step was required in this process.

Graphical abstract: Copper-mediated C(sp2)–H amination using TMSN3 as a nitrogen source: redox-neutral access to primary anilines

Supplementary files

Article information

Article type
Research Article
Submitted
16 May 2014
Accepted
23 Jun 2014
First published
24 Jun 2014

Org. Chem. Front., 2014,1, 777-781

Author version available

Copper-mediated C(sp2)–H amination using TMSN3 as a nitrogen source: redox-neutral access to primary anilines

J. Peng, M. Chen, Z. Xie, S. Luo and Q. Zhu, Org. Chem. Front., 2014, 1, 777 DOI: 10.1039/C4QO00143E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements