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Issue 3, 2014
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Sterically demanding aryl–alkyl Suzuki–Miyaura coupling

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Abstract

Efficient sterically demanding aryl–alkyl Suzuki–Miyaura coupling between di-ortho-substituted aryl halides and secondary alkylboronic acids has been achieved with a Pd-AntPhos catalyst that has shown high reactivity and a broad substrate scope with unprecedented steric hindrance. The methodology has facilitated the synthesis of molecular gears such as by cross-coupling.

Graphical abstract: Sterically demanding aryl–alkyl Suzuki–Miyaura coupling

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Publication details

The article was received on 22 Jan 2014, accepted on 19 Feb 2014 and first published on 17 Mar 2014


Article type: Research Article
DOI: 10.1039/C4QO00024B
Author version available: Download Author version (PDF)
Citation: Org. Chem. Front., 2014,1, 225-229
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    Sterically demanding aryl–alkyl Suzuki–Miyaura coupling

    C. Li, G. Xiao, Q. Zhao, H. Liu, T. Wang and W. Tang, Org. Chem. Front., 2014, 1, 225
    DOI: 10.1039/C4QO00024B

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