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Issue 1, 2014
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Transmetalation of Ar1ZnX with [Ar2–Pd–X] is the rate-limiting step: kinetic insights from a live Pd-catalyzed Negishi coupling

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Abstract

Transmetalation is the rate-limiting step in Negishi coupling: in a live “Pd-catalyzed Negishi coupling of ArI with Ar′ZnX”, the transmetalation was assigned as the rate-limiting step through kinetic investigation. Quantitative measurements of the transmetalation of ArZnX with [Ar–Pd–X] from this live Pd-catalyzed coupling reaction were obtained and the activation enthalpy is 11.3 kcal mol−1.

Graphical abstract: Transmetalation of Ar1ZnX with [Ar2–Pd–X] is the rate-limiting step: kinetic insights from a live Pd-catalyzed Negishi coupling

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The article was received on 26 Oct 2013, accepted on 25 Nov 2013 and first published on 19 Dec 2013


Article type: Research Article
DOI: 10.1039/C3QO00021D
Citation: Org. Chem. Front., 2014,1, 50-53
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    Transmetalation of Ar1ZnX with [Ar2–Pd–X] is the rate-limiting step: kinetic insights from a live Pd-catalyzed Negishi coupling

    J. Li, L. Jin, C. Liu and A. Lei, Org. Chem. Front., 2014, 1, 50
    DOI: 10.1039/C3QO00021D

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