Issue 24, 2014
From the journal:

Polymer Chemistry

Fabrication of thermoresponsive nanogels by thermo-nanoprecipitation and in situ encapsulation of bioactives†

Michael Giulbudagian,‡a   Mazdak Asadian-Birjand,‡a   Dirk Steinhilber,a   Katharina Achazi,a   Maria Molinaa  and  Marcelo Calderón ORCID logo *ab  

* Corresponding authors

a Freie Universität Berlin, Institute of Chemistry and Biochemistry, Takustr. 3, 14195 Berlin, Germany

b Helmholtz Virtuelles Institut – Multifunctional Biomaterials for Medicine, Helmholtz-Zentrum Geesthacht, Teltow, Germany
E-mail: marcelo.calderon@fu-berlin.de
Web: http://www.bcp.fu-berlin.de

Abstract

A synthetic method for thermoresponsive, glycerol based nanogels has been developed. The nanogels were synthesized by nanoprecipitation of the orthogonally functionalized macromonomers and their gelation in water. The crosslinking points were generated by strain promoted azide–alkyne cycloaddition which enabled the in situ encapsulation of Doxorubicin HCl. The mild and surfactant free reaction conditions make these nanogels ideal candidates for biomedical applications.

Graphical abstract: Fabrication of thermoresponsive nanogels by thermo-nanoprecipitation and in situ encapsulation of bioactives

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Article information

DOI
https://doi.org/10.1039/C4PY01186D
Article type
Communication
Submitted
27 Aug 2014
Accepted
12 Sep 2014
First published
15 Sep 2014
This article is Open Access
Creative Commons BY-NC license

Polym. Chem., 2014,5, 6909-6913

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Fabrication of thermoresponsive nanogels by thermo-nanoprecipitation and in situ encapsulation of bioactives

M. Giulbudagian, M. Asadian-Birjand, D. Steinhilber, K. Achazi, M. Molina and M. Calderón, Polym. Chem., 2014, 5, 6909 DOI: 10.1039/C4PY01186D

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