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Issue 19, 2014
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Catch and release: photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery

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Abstract

Binding interactions between DNA and cationic nanocarriers must be sufficiently strong to prevent nuclease-mediated degradation, yet weak enough to permit transcription. We demonstrate cationic diblock copolymers containing PEG and o-nitrobenzyl moieties that facilitated tailorable DNA complexation and light-activated release. This design unlocks a new approach to improved non-viral gene packaging.

Graphical abstract: Catch and release: photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery

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Publication details

The article was received on 06 May 2014, accepted on 04 Jun 2014 and first published on 05 Jun 2014


Article type: Communication
DOI: 10.1039/C4PY00638K
Citation: Polym. Chem., 2014,5, 5535-5541
  • Open access: Creative Commons BY license
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    Catch and release: photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery

    M. D. Green, A. A. Foster, C. T. Greco, R. Roy, R. M. Lehr, T. H. Epps, III and M. O. Sullivan, Polym. Chem., 2014, 5, 5535
    DOI: 10.1039/C4PY00638K

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