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Issue 5, 2014
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Voltage-responsive micelles based on the assembly of two biocompatible homopolymers

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Abstract

Voltage stimulus is considered as a clean and simple method in the field of stimuli-responsive polymer systems, in which the system based on β-cyclodextrin (β-CD) and ferrocene (Fc) has attracted considerable attention. Herein, we report voltage-responsive micelles based on the assembly of two biocompatible homopolymers, namely, the poly(ethylene glycol) homopolymer modified with β-CD (PEG–β-CD) and the poly(L-lactide) homopolymer modified with Fc (PLLA–Fc). Through host–guest interactions between β-CD and Fc, the two homopolymers connect together, forming a non-covalent supramolecular block copolymer PLLA–Fc/PEG–β-CD. PLLA–Fc/PEG–β-CD can further self-assemble to form stable micelles in aqueous solution. Through electrochemical control, a reversible assembly–disassembly transition of this micellar system was realized. Voltage-controlled drug release based on this system was also conducted successfully.

Graphical abstract: Voltage-responsive micelles based on the assembly of two biocompatible homopolymers

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Publication details

The article was received on 01 Sep 2013, accepted on 17 Oct 2013 and first published on 18 Oct 2013


Article type: Paper
DOI: 10.1039/C3PY01204B
Citation: Polym. Chem., 2014,5, 1751-1759
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    Voltage-responsive micelles based on the assembly of two biocompatible homopolymers

    L. Peng, A. Feng, H. Zhang, H. Wang, C. Jian, B. Liu, W. Gao and J. Yuan, Polym. Chem., 2014, 5, 1751
    DOI: 10.1039/C3PY01204B

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