Issue 2, 2014
From the journal:

Polymer Chemistry

Cationic polythiophenes as responsive DNA-binding polymers†

Analyn C. Carreon,abc   Webster L. Santos,b   John B. Matson*b  and  Regina C. So*a  

* Corresponding authors

a Department of Chemistry, Ateneo de Manila University, Schmitt Hall, Loyola Heights, Katipunan, Quezon City 1108, Philippines
E-mail: rso@ateneo.edu
Fax: +63 2 4261323
Tel: +63 2 4266001 ext. 5620

b Department of Chemistry, Virginia Tech, 800 West Campus Drive, Blacksburg, VA 24061, USA
E-mail: jbmatson@vt.edu
Fax: +1 540 2313255
Tel: +1 540 2313329

c Department of Chemistry, Xavier University – Ateneo de Cagayan University, Corrales Avenue, Cagayan de Oro City 9000, Philippines
E-mail: acarreon@xu.edu.ph
Fax: +63 8822 723116 2029
Tel: +63 88 8583116 ext. 3110

Abstract

A new water soluble cationic polythiophene derivative, poly(N,N,N-trimethyl-3-(2-(thiophen-3-yl)acetamido)propan-1-aminium iodide), was synthesized via two consecutive post-polymerization functionalizations of poly(methyl 2-(thiophen-3-yl)acetate). This conjugated polymer binds DNA at N/P = 5 and forms polyplexes at N/P = 10. Its potential use as a theranostic gene delivery vehicle is investigated here.

Graphical abstract: Cationic polythiophenes as responsive DNA-binding polymers

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Article information

DOI
https://doi.org/10.1039/C3PY01069D
Article type
Communication
Submitted
07 Aug 2013
Accepted
29 Aug 2013
First published
23 Sep 2013
This article is Open Access
Creative Commons BY-NC license

Polym. Chem., 2014,5, 314-317

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Cationic polythiophenes as responsive DNA-binding polymers

A. C. Carreon, W. L. Santos, J. B. Matson and R. C. So, Polym. Chem., 2014, 5, 314 DOI: 10.1039/C3PY01069D

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