Issue 2, 2015

Novel synthesis of 5-methyl-5,10-dihydroindolo[3,2-b]indoles by Pd-catalyzed C–C and two-fold C–N coupling reactions

Abstract

A series of 5,10-dihydroindolo[3,2-b]indoles was successfully prepared by an efficient two-step strategy based on site-selective Pd-catalyzed cross-coupling reaction with N-methyl-2,3-dibromoindole and subsequent cyclization by two-fold Pd-catalyzed C–N coupling with amines. The products show a strong fluorescence.

Graphical abstract: Novel synthesis of 5-methyl-5,10-dihydroindolo[3,2-b]indoles by Pd-catalyzed C–C and two-fold C–N coupling reactions

Supplementary files

Article information

Article type
Paper
Submitted
12 Aug 2014
Accepted
21 Oct 2014
First published
22 Oct 2014

Org. Biomol. Chem., 2015,13, 583-591

Author version available

Novel synthesis of 5-methyl-5,10-dihydroindolo[3,2-b]indoles by Pd-catalyzed C–C and two-fold C–N coupling reactions

T. Q. Hung, S. Hancker, A. Villinger, S. Lochbrunner, T. T. Dang, A. Friedrich, W. Breitsprecher and P. Langer, Org. Biomol. Chem., 2015, 13, 583 DOI: 10.1039/C4OB01723D

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