Synthesis and characterisation of glucosamine–NSAID bioconjugates

Rachel A. Jones; Yann Thillier; Siva S. Panda; Nicole Rivera Rosario; C. Dennis Hall; Alan R. Katritzky

doi:10.1039/C4OB01681E

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Synthesis and characterisation of glucosamine–NSAID bioconjugates†

Rachel A. Jones,

*^a Yann Thillier,^a Siva S. Panda,^a Nicole Rivera Rosario,^a C. Dennis Hall*^a and Alan R. Katritzky ‡^ab

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* Corresponding authors

^a Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA
E-mail: rajones@ufl.edu, charlesdennishall@gmail.com
Tel: +1-352-392-0554

^b Chemistry Department, Faculty of Science, King Adbulaziz University, P. O. Box 80203, Jeddah, Saudi Arabia

Abstract

Strategies to couple non-steroidal anti-inflammatory drugs (NSAIDs) to a glucosamine hydrochloride salt via an amino acid linker are investigated and a series of novel NSAID–glucosamine bioconjugates have been prepared.

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Article information

DOI: https://doi.org/10.1039/C4OB01681E
Article type: Paper
Submitted: 06 Aug 2014
Accepted: 04 Sep 2014
First published: 12 Sep 2014

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Org. Biomol. Chem., 2014,12, 8325-8335

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Synthesis and characterisation of glucosamine–NSAID bioconjugates

R. A. Jones, Y. Thillier, S. S. Panda, N. Rivera Rosario, C. D. Hall and A. R. Katritzky, Org. Biomol. Chem., 2014, 12, 8325 DOI: 10.1039/C4OB01681E

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Organic & Biomolecular Chemistry

Synthesis and characterisation of glucosamine–NSAID bioconjugates†

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Synthesis and characterisation of glucosamine–NSAID bioconjugates

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