Issue 44, 2014

Solvent switchable cycloaddition: a (one-pot) metal-free approach towards N-substituted benzo[e]- or [f]isoindolones via Csp2–H functionalization

Abstract

The tuning of selective ring closure is a nontrivial challenge in synthetic organic chemistry. Herein we report a solvent switchable metal-free [4 + 2] cycloaddition approach via Csp2–H functionalization. The protocol is highly atom economical with water being the only by-product, delivering N-substituted benzo[e]- or [f]isoindolones in high yields.

Graphical abstract: Solvent switchable cycloaddition: a (one-pot) metal-free approach towards N-substituted benzo[e]- or [f]isoindolones via Csp2–H functionalization

Supplementary files

Article information

Article type
Paper
Submitted
01 Aug 2014
Accepted
17 Sep 2014
First published
18 Sep 2014
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2014,12, 8861-8865

Solvent switchable cycloaddition: a (one-pot) metal-free approach towards N-substituted benzo[e]- or [f]isoindolones via Csp2–H functionalization

P. A. Ambasana, D. D. Vachhani, M. Galli, J. Jacobs, L. Van Meervelt, A. K. Shah and E. V. Van der Eycken, Org. Biomol. Chem., 2014, 12, 8861 DOI: 10.1039/C4OB01644K

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