Issue 35, 2014
From the journal:

Organic & Biomolecular Chemistry

l-Rhamnose-containing supramolecular nanofibrils as potential immunosuppressive materials†

Fan Zhao, ORCID logo ‡a   Balthasar A. Heesters,‡bc   Isaac Chiu,d   Yuan Gao,a   Junfeng Shi,a   Ning Zhou,a   Michael C. Carroll*b  and  Bing Xu ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Brandeis University, 415 South St. MS015, Waltham, Massachusetts 02454, USA
E-mail: bxu@brandeis.edu

b Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
E-mail: Michael.Carroll@childrens.harvard.edu

c Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands

d Department of Microbiology and Immunobiology, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA 0211

Abstract

An L-rhamnose-based hydrogelator self-assembles to form nanofibrils, which, in contrast to the properties of monomeric L-rhamnose, suppress the antibody response of mice to phycoerythrin (PE), a fluorescent protein antigen. As the first example of the supramolecular assemblies of a saccharide to suppress immunity, this work illustrates a new approach of immunomodulation.

Graphical abstract: l-Rhamnose-containing supramolecular nanofibrils as potential immunosuppressive materials

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Article information

DOI
https://doi.org/10.1039/C4OB01362J
Article type
Communication
Submitted
30 Jun 2014
Accepted
23 Jul 2014
First published
23 Jul 2014

Org. Biomol. Chem., 2014,12, 6816-6819

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L-Rhamnose-containing supramolecular nanofibrils as potential immunosuppressive materials

F. Zhao, B. A. Heesters, I. Chiu, Y. Gao, J. Shi, N. Zhou, M. C. Carroll and B. Xu, Org. Biomol. Chem., 2014, 12, 6816 DOI: 10.1039/C4OB01362J

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