Diaporine, a novel endophyte-derived regulator of macrophage differentiation

Hao Chen Wu; Hui Ming Ge; Le Yun Zang; Yun Cheng Bei; Zhi Yuan Niu; Wei Wei; Xiu Jing Feng; Sen Ding; Seik Weng Ng; Ping Ping Shen; Ren Xiang Tan

doi:10.1039/C4OB01123F

Diaporine, a novel endophyte-derived regulator of macrophage differentiation†

Hao Chen Wu,‡^a Hui Ming Ge,‡^a Le Yun Zang,^a Yun Cheng Bei,^a Zhi Yuan Niu,^a Wei Wei,^a Xiu Jing Feng,^a Sen Ding,^a Seik Weng Ng,^bc Ping Ping Shen*^a and Ren Xiang Tan*^a

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^a State Key Laboratory of Pharmaceutical Biotechnology, and Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, P. R. China
E-mail: rxtan@nju.edu.cn, ppshen@nju.edu.cn

^b Department of Chemistry, University of Malaya, Kuala Lumpur 50603, Malaysia

^c Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 80203, Saudi Arabia

Abstract

Diaporine (1), an unprecedented symmetric polyketide, was characterized from the endophytic fungus. The structure was determined by extensive spectroscopic analyses. Diaporine can inhibit significantly the differentiation of macrophages and has potential to induce conversion from the M2 to the M1 phenotype, in addition to regulation of the TLR4-MAPK signal pathway and PPARγ activity.

Organic & Biomolecular Chemistry

Diaporine, a novel endophyte-derived regulator of macrophage differentiation†

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