Transition-metal-free oxidative carboazidation of acrylamides via cascade C–N and C–C bond-forming reactions

Abstract

A novel transition-metal-free oxidative carboazidation of acrylamides using inexpensive NaN₃ and K₂S₂O₈ was achieved, which not only provided an efficient method to prepare various N₃-substituted oxindoles, but also represented a novel strategy for C–N and C–C bond formation via a free-radical cascade process. This transformation exhibits excellent functional group tolerance, affording the desired oxindoles in good to excellent yields.