Issue 24, 2014

Versatile post-functionalization of the external shell of cowpea chlorotic mottle virus by using click chemistry

Abstract

We present the modification of the outer protein shell of cowpea chlorotic mottle virus (CCMV) with linear and strained alkyne groups. These functionalized protein capsids constitute valuable platforms for post-functionalization via click chemistry. After modification, the integrity of the capsid and the reversible disassembly behavior are preserved.

Graphical abstract: Versatile post-functionalization of the external shell of cowpea chlorotic mottle virus by using click chemistry

Supplementary files

Article information

Article type
Communication
Submitted
06 Mar 2014
Accepted
29 Apr 2014
First published
09 May 2014

Org. Biomol. Chem., 2014,12, 4065-4069

Author version available

Versatile post-functionalization of the external shell of cowpea chlorotic mottle virus by using click chemistry

C. A. Hommersom, B. Matt, A. van der Ham, J. J. L. M. Cornelissen and N. Katsonis, Org. Biomol. Chem., 2014, 12, 4065 DOI: 10.1039/C4OB00505H

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