Synthesis of a multibranched porphyrin–oligonucleotide scaffold for the construction of DNA-based nano-architectures

Abstract

The interest in the functionalization of oligonucleotides with organic molecules has grown considerably over the last decade. In this work, we report on the synthesis and characterization of porphyrin–oligonucleotide hybrids containing one to four DNA strands (P₁–P₄). The hybrid P₄, which inserts one porphyrin and four DNA fragments, was combined with gold nanoparticles and imaged by transmission electron microscopy.