Issue 21, 2014

Direct olefination of benzaldehydes into 1,3-diarylpropenes via a copper-catalyzed heterodomino Knoevenagel-decarboxylation-Csp3-H activation sequence

Abstract

Copper-catalyzed direct olefination of benzaldehydes into 1,3-diarylpropenes by a novel domino Knoevenagel-decarboxylation-Csp3-H activation sequence is reported. This method provides a concise and effective route toward the synthesis of unsymmetrical 1,3-diarylpropene derivatives.

Graphical abstract: Direct olefination of benzaldehydes into 1,3-diarylpropenes via a copper-catalyzed heterodomino Knoevenagel-decarboxylation-Csp3-H activation sequence

Supplementary files

Article information

Article type
Paper
Submitted
21 Jan 2014
Accepted
26 Mar 2014
First published
26 Mar 2014
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2014,12, 3493-3498

Author version available

Direct olefination of benzaldehydes into 1,3-diarylpropenes via a copper-catalyzed heterodomino Knoevenagel-decarboxylation-Csp3-H activation sequence

Y. Zhao, L. Sun, T. Zeng, J. Wang, Y. Peng and G. Song, Org. Biomol. Chem., 2014, 12, 3493 DOI: 10.1039/C4OB00155A

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