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Issue 13, 2014
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Direct sp3 C–H acroleination of N-aryl-tetrahydroisoquinolines by merging photoredox catalysis with nucleophilic catalysis

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Abstract

Sequence catalysis merging photoredox catalysis (PC) and nucleophilic catalysis (NC) has been realized for the direct sp3 C–H acroleination of N-aryl-tetrahydroisoquinoline (THIQ). The reaction was performed under very mild conditions and afforded products in 50–91% yields. A catalytic asymmetric variant was proved to be successful with moderate enantioselectivities (up to 83 : 17 er).

Graphical abstract: Direct sp3 C–H acroleination of N-aryl-tetrahydroisoquinolines by merging photoredox catalysis with nucleophilic catalysis

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Publication details

The article was received on 09 Dec 2013, accepted on 28 Jan 2014 and first published on 28 Jan 2014


Article type: Communication
DOI: 10.1039/C3OB42453G
Author version available: Download Author version (PDF)
Citation: Org. Biomol. Chem., 2014,12, 2037-2040
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    Direct sp3 C–H acroleination of N-aryl-tetrahydroisoquinolines by merging photoredox catalysis with nucleophilic catalysis

    Z. Feng, J. Xuan, X. Xia, W. Ding, W. Guo, J. Chen, Y. Zou, L. Lu and W. Xiao, Org. Biomol. Chem., 2014, 12, 2037
    DOI: 10.1039/C3OB42453G

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