A mild and efficient chemoselective N-deacetylation using the Schwartz reagent at room temperature in rapid time is described. The mild and neutral conditions enable orthogonal N-deacetylation in the presence of some of the common protecting groups (viz. Boc, Fmoc, Cbz, Ts). The deprotection conditions did not induce any epimerization at the chiral amino centre.
P. R. Sultane, T. B. Mete and R. G. Bhat, Org. Biomol. Chem., 2014, 12, 261 DOI: 10.1039/C3OB41971A
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