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Issue 18, 2016
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Single-molecule detection at high concentrations with optical aperture nanoantennas

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Abstract

Single-molecule detection has become an indispensable technology in life science, and medical research. In order to get meaningful information on many biological processes, single-molecule analysis is required in micro-molar concentrations. At such high concentrations, it is very challenging to isolate a single molecule with conventional diffraction-limited optics. Recently, optical aperture nanoantennas (OANs) have emerged as a powerful tool to enhance the single-molecule detection under a physiological environment. The OANs, which consist of nano-scale apertures on a metallic film, have the following unique properties: (1) nanoscale light confinement; (2) enhanced fluorescence emission; (3) tunable radiation pattern; (4) reduced background noise; and (5) massive parallel detection. This review presents the fundamentals, recent developments and future perspectives in this emerging field.

Graphical abstract: Single-molecule detection at high concentrations with optical aperture nanoantennas

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Publication details

The article was received on 26 Feb 2016, accepted on 12 Apr 2016 and first published on 12 Apr 2016


Article type: Review Article
DOI: 10.1039/C6NR01645F
Citation: Nanoscale, 2016,8, 9480-9487
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    Single-molecule detection at high concentrations with optical aperture nanoantennas

    M. S. Alam, F. Karim and C. Zhao, Nanoscale, 2016, 8, 9480
    DOI: 10.1039/C6NR01645F

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