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Issue 22, 2015
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Low affinity binding of plasma proteins to lipid-coated quantum dots as observed by in situ fluorescence correlation spectroscopy

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Abstract

Protein binding to lipid-coated nanoparticles has been pursued quantitatively by using fluorescence correlation spectroscopy. The binding of three important plasma proteins to lipid-enwrapped quantum dots (QDs) shows very low affinity, with an apparent dissociation coefficient in the range of several hundred micromolar. Thus, the tendency to adsorb is orders of magnitude weaker than for QDs coated with dihydrolipoic acid.

Graphical abstract: Low affinity binding of plasma proteins to lipid-coated quantum dots as observed by in situ fluorescence correlation spectroscopy

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Publication details

The article was received on 16 Mar 2015, accepted on 29 Apr 2015 and first published on 01 May 2015


Article type: Communication
DOI: 10.1039/C5NR01694K
Author version available: Download Author version (PDF)
Citation: Nanoscale, 2015,7, 9980-9984
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    Low affinity binding of plasma proteins to lipid-coated quantum dots as observed by in situ fluorescence correlation spectroscopy

    Y. Klapper, P. Maffre, L. Shang, K. N. Ekdahl, B. Nilsson, S. Hettler, M. Dries, D. Gerthsen and G. U. Nienhaus, Nanoscale, 2015, 7, 9980
    DOI: 10.1039/C5NR01694K

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