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Issue 23, 2014
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DNA origami nanopores: developments, challenges and perspectives

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Abstract

DNA nanotechnology has enabled the construction of DNA origami nanopores; synthetic nanopores that present improved capabilities for the area of single molecule detection. Their extraordinary versatility makes them a new and powerful tool in nanobiotechnology for a wide range of important applications beyond molecular sensing. In this review, we briefly present the recent developments in this emerging field of research. We discuss the current challenges and possible solutions that would enhance the sensing capabilities of DNA origami nanopores. Finally, we anticipate novel avenues for future research and highlight a range of exciting ideas and applications that could be explored in the near future.

Graphical abstract: DNA origami nanopores: developments, challenges and perspectives

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Publication details

The article was received on 19 Jul 2014, accepted on 06 Oct 2014 and first published on 07 Oct 2014


Article type: Minireview
DOI: 10.1039/C4NR04094E
Citation: Nanoscale, 2014,6, 14121-14132
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    DNA origami nanopores: developments, challenges and perspectives

    S. Hernández-Ainsa and U. F. Keyser, Nanoscale, 2014, 6, 14121
    DOI: 10.1039/C4NR04094E

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