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Issue 13, 2014
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Functionalization of protein-based nanocages for drug delivery applications

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Abstract

Traditional drug delivery strategies involve drugs which are not targeted towards the desired tissue. This can lead to undesired side effects, as normal cells are affected by the drugs as well. Therefore, new systems are now being developed which combine targeting functionalities with encapsulation of drug cargo. Protein nanocages are highly promising drug delivery platforms due to their perfectly defined structures, biocompatibility, biodegradability and low toxicity. A variety of protein nanocages have been modified and functionalized for these types of applications. In this review, we aim to give an overview of different types of modifications of protein-based nanocontainers for drug delivery applications.

Graphical abstract: Functionalization of protein-based nanocages for drug delivery applications

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Publication details

The article was received on 18 Feb 2014, accepted on 02 May 2014 and first published on 09 May 2014


Article type: Review Article
DOI: 10.1039/C4NR00915K
Author version available: Download Author version (PDF)
Citation: Nanoscale, 2014,6, 7124-7141
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    Functionalization of protein-based nanocages for drug delivery applications

    L. Schoonen and J. C. M. van Hest, Nanoscale, 2014, 6, 7124
    DOI: 10.1039/C4NR00915K

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