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Issue 7, 2014
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Near-infrared light-responsive supramolecular nanovalve based on mesoporous silica-coated gold nanorods

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Abstract

We constructed a novel cancer theranostic hybrid platform, based on mesoporous silica-coated gold nanorods (AuNR@MSN) gated by sulfonatocalix[4]arene (SC[4]A) switches, for bio-friendly near-infrared (NIR) light-triggered cargo release in a remote and stepwise fashion. The advantages of supramolecular switches, mesoporous silicas, and AuNRs were combined in one drug delivery system. Mesoporous silicas coated on AuNRs guarantee a high drug payload and can be easily post-functionalized. Significantly, the plasmonic heating from the NIR light-stimulated AuNR cores can decrease the ring-stalk binding affinity, leading to the dissociation of SC[4]A rings from the stalks, thus opening the nanovalves and releasing the cargos. The NIR light-responsive mechanized AuNR@MSN offers exciting prospects for non-invasive controlled drug delivery, being more effective and safer than other techniques.

Graphical abstract: Near-infrared light-responsive supramolecular nanovalve based on mesoporous silica-coated gold nanorods

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Publication details

The article was received on 18 Jan 2014, accepted on 16 Mar 2014 and first published on 17 Mar 2014


Article type: Edge Article
DOI: 10.1039/C4SC00198B
Citation: Chem. Sci., 2014,5, 2804-2808
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    Near-infrared light-responsive supramolecular nanovalve based on mesoporous silica-coated gold nanorods

    H. Li, L. Tan, P. Jia, Q. Li, Y. Sun, J. Zhang, Y. Ning, J. Yu and Y. Yang, Chem. Sci., 2014, 5, 2804
    DOI: 10.1039/C4SC00198B

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