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Issue 11, 2014
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Recent advances in the field of bioactive tetronates

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Abstract

Covering: up to mid-2014

Over the last several decades, the number of pharmacologically active natural products has significantly increased and several natural product families have taken shape. This review highlights the family of tetronate and spirotetronate compounds, which show a vast structural and functional diversity. The rapid growth of this group has created the need for a comprehensive overview and classification system, which we have devised based on structural characteristics. An updated overview is provided based on known tetronates, intended to spur further research in this field by identifying common structural features and general principles of their biosynthesis. We also compare a selection of chemical syntheses of representative compounds belonging to individual subtypes, both in terms of their efficiency as well as the extent to which they are biomimetic. This review also summarizes progress in unraveling some of the principles underlying the potent and varied bioactivities of natural tetronate antibiotics, and in identifying and better understanding their structure–activity relationships and modes of action.

Graphical abstract: Recent advances in the field of bioactive tetronates

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Publication details

The article was received on 07 Feb 2014 and first published on 25 Jun 2014


Article type: Review Article
DOI: 10.1039/C4NP00015C
Citation: Nat. Prod. Rep., 2014,31, 1554-1584
  • Open access: Creative Commons BY license
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    Recent advances in the field of bioactive tetronates

    L. Vieweg, S. Reichau, R. Schobert, P. F. Leadlay and R. D. Süssmuth, Nat. Prod. Rep., 2014, 31, 1554
    DOI: 10.1039/C4NP00015C

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