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Issue 10, 2014
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Epidithiodioxopiperazines. occurrence, synthesis and biogenesis

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Abstract

Covering: 1936 to 2013

Epidithiodioxopiperazine alkaloids possess an astonishing array of molecular architecture and generally exhibit potent biological activity. Nearly twenty distinct families have been isolated and characterized since the seminal discovery of gliotoxin in 1936. Numerous biosynthetic investigations offer a glimpse at the relative ease with which Nature is able to assemble this class of molecules, while providing synthetic chemists inspiration for the development of more efficient syntheses. Herein, we discuss the isolation and characterization, proposed fungal biogeneses, and total syntheses of epidithiodioxopiperazines.

Graphical abstract: Epidithiodioxopiperazines. occurrence, synthesis and biogenesis

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Publication details

The article was received on 17 Sep 2013 and first published on 09 May 2014


Article type: Review Article
DOI: 10.1039/C3NP70097F
Citation: Nat. Prod. Rep., 2014,31, 1376-1404
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    Epidithiodioxopiperazines. occurrence, synthesis and biogenesis

    T. R. Welch and R. M. Williams, Nat. Prod. Rep., 2014, 31, 1376
    DOI: 10.1039/C3NP70097F

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