Issue 2, 2015

Synthesis of unsymmetrical phenylurea derivatives via oxidative cross coupling of aryl formamides with amines under metal-free conditions

Abstract

A new synthetic approach for phenylurea derivatives involving the cross coupling of N-aryl formamides with amines through the formation of isocyanate intermediates in the presence of hypervalent iodine reagents is described.

Graphical abstract: Synthesis of unsymmetrical phenylurea derivatives via oxidative cross coupling of aryl formamides with amines under metal-free conditions

Supplementary files

Article information

Article type
Letter
Submitted
27 Sep 2014
Accepted
18 Nov 2014
First published
19 Nov 2014

New J. Chem., 2015,39, 805-809

Synthesis of unsymmetrical phenylurea derivatives via oxidative cross coupling of aryl formamides with amines under metal-free conditions

N. V. Reddy, P. S. Kumar, P. S. Reddy, M. L. Kantam and K. R. Reddy, New J. Chem., 2015, 39, 805 DOI: 10.1039/C4NJ01668H

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